Ga-68-CXCR4 PET/CT in Indolent B-cell Lymphoma

Recruiting now · Phase 2

Conditions studied: Indolent B-Cell Non-Hodgkin Lymphoma

In brief

This study explores the efficacy of Ga-68-PentixaFor PET/CT in detecting, assessing treatment response, and monitoring the risk of aggressiveness in indolent B-cell lymphoma. The background introduces CXCR4 and discusses its role in cancer research. Currently, FDG-PET is the primary imaging tool for lymphoma staging, but it lacks diagnostic accuracy for low-grade lymphomas. Ga-68-PentixaFor PET demonstrates promising detection capabilities across various lymphomas, suggesting its potential as a superior imaging modality for low-grade lymphomas.

Key facts

Study ID

NCT06461182

Run by

Koo Foundation Sun Yat-Sen Cancer Center

People needed

15

Starts

2024-04-29

Expected to finish

2027-04-01

Last updated by the study team

2024-06-14

Who can join

Age: 20 and older, up to 100. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• The pathological diagnosis is slow-growing lymphoma, such as: marginal-zone B-cell lymphoma, Waldenstrom macroglobulinemia lymphocytic lymphoma, CLL/SLL, mantle cell lymphoma.
• Have undergone or planned to undergo FDG PET scan for indications including initial staging, therapeutic response evaluation, or follow-up examinations within 3 to 6 months in the clinical observation group.
• Able to lie flat for at least 30 minutes.
• Signing the subject consent form.
• ECOG grade 0-2.
• The timing of F-18-FDG usage in this trial follows the "Lymphoma Treatment Principles" of our institution.

You may not qualify if…

• Pregnant woman
• Severe renal impairment (eGRF< 30ml/min)
• Known or suspected allergy to radiopharmaceuticals
• Concurrent or previous diagnosis of malignancies other than lymphoma
• Inability to undergo the necessary PET scan procedure
• Refusal or unwillingness to sign the informed consent form
• Severe medical conditions (severe disabilities, mental disorders)

Where it is running

• Koo Foundation Sun Yat-Sen Cancer Center — Taipei, Beitou, Taiwan (enrolling)

Full record on ClinicalTrials.gov

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