Pilot Study on Evaluating the Geroprotective Effect of Metformin
Recruiting now · Phase 2 · Has a placebo group
Conditions studied: Metformin, Aging
In brief
The objective of this research is to assess the efficacy of oral metformin in mitigating the aging process in middle-aged and elderly males, to pinpoint sensitive indicators of human senescence, and to offer innovative frameworks and scientific insights for pharmaceutical interventions in aging.
Key facts
- Study ID
- NCT06459310
- Run by
- Xuanwu Hospital, Beijing
- People needed
- 130
- Starts
- 2024-06-30
- Expected to finish
- 2028-07-31
- Last updated by the study team
- 2025-03-21
Who can join
Age: 18 and older, up to 65. Sex: male. Healthy volunteers: accepted.
You may not qualify if…
- Severe chronic or acute disease: cancer, clinically significant congestive heart failure, chronic obstructive pulmonary disease (COPD), previous or new-onset diabetes, inflammatory state, serum creatinine >1.5 mg/dl , active liver disease, History of metabolic acidosis, poorly controlled hypertension, epilepsy, recent (within 3 months) cardiovascular events (MI, PTCA, CABG, stroke), severe renal insufficiency, inflammatory bowel disease, persistent glucocorticoids Treatment; neurological diseases such as dementia, AD, PD, etc.; infectious diseases such as HIV, hepatitis, tuberculosis, etc.; severe autoimmune diseases;
- BMI<18.5 or BMI>30;
- Persistent alcohol or drug abuse;
- Treatment with drugs known to affect glucose metabolism (other diabetes drugs, systemic glucocorticoids, niacin);
- Hypersensitivity to metformin or any component of the preparation;
- Have taken metformin, low-dose aspirin, acarbose, vitamin C in the recent (3 months);
- Unable to provide informed consent;
- Other circumstances in which the researcher believes that the physical factors of the participants may adversely affect the research process or results.
Where it is running
- Xuanwu Hospital Capital Medical University — Beijing, China (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.