MRSI Evaluation for Minor Stroke With Large Vessel Occlusion
Recruiting now
Conditions studied: Acute Ischemic Stroke
In brief
The goal of this observational study is to understand acute anterior circulation large artery occluded minor stroke (LVO-MIS) evolution using magnetic resonance spectroscopic imaging evaluation. The main questions it aims to answer are: 1. Neurometabolic predictors of early neurological deterioration and functional outcome; 2. Temporal and spatial dynamic changes of the neurometabolites from the acute stage (within 24 hours), through the subacute stage (5-7 days), to the chronic stage (90 days); 3. Temporal and spatial dynamic changes of the neurotransmitters GABA, glutamate, and glutamine from the acute stage to the chronic stage; 4. Brain regions exhibiting changes in whole-brain metabolic network connectivity.
Key facts
- Study ID
- NCT06457217
- Run by
- Shanghai 6th People's Hospital
- People needed
- 75
- Starts
- 2024-08-15
- Expected to finish
- 2027-12-30
- Last updated by the study team
- 2024-10-16
Who can join
Age: 18 and older, up to 100. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adult (age ≥ 18 years) patients presenting with symptoms consistent with acute ischemic stroke due to occlusion of the intracranial internal carotid artery and/or M1 or M2 segment of the middle cerebral artery;
- Patients with mild symptoms at admission (National Institutes of Health Stroke Scale (NIHSS)<6);
- Baseline multimodal-CT imaging, including NCCT, CTA and CTP, performed at the trial-site hospital;
- Time from symptom onset or last known normal to enrollment is less than 24 hours;
- Patient or legal representative willing to comply with protocol requirements and data collection procedures, understand and sign informed consent.
You may not qualify if…
- A pre-incident mRS ≥ 1 point before onset;
- Previous clear history of cerebral infarction, cerebral hemorrhage, brain tumor and other diseases that affect cerebral metabolism;
- Intolerance or non-cooperation with magnetic resonance examination;
- Severe cardiac, hepatic, renal impairment or other systemic serious advanced diseases;
- Pregnancy or lactation;
- Life expectancy is less than 3 months;
- Other conditions that, in the opinion of the investigator, are not suitable for participation in this study or may pose a significant risk to the patient (such as inability to understand and/or comply with study procedures and/or follow-up due to psychiatric disorders, cognitive or emotional disorders).
Where it is running
- Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine — Shanghai, Shanghai Municipality, China (enrolling)
Full record on ClinicalTrials.gov
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