Multi-Center Project: Building Electronic Tools To Enhance and Reinforce CArdiovascular REcommendations - Heart Failure

Completed · Not applicable

Conditions studied: Heart Failure

In brief

This study will test an automated, electronic health record (EHR-)embedded alert to improve prescribing of guideline-directed medical therapy for patients with heart failure and reduced ejection fraction (HFrEF). The investigators have previously tested and implemented this alert at NYU Langone Health (NYULH), and will now test and implement this alert across three other health systems.

Key facts

Study ID

NCT06457152

Run by

NYU Langone Health

People needed

1136

Starts

2025-04-04

Expected to finish

2026-03-29

Last updated by the study team

2026-05-05

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient with an encounter visit at participating cardiology practice during the study period
• Patient with EF of less than or equal to 40% on most recent echocardiogram at the time of visit
• Patient ages 18-90

You may not qualify if…

• Pregnancy
• Ventricular assist device
• Hospice
• Cardiac amyloid
• Medication-specific exclusion for MRA: most recent systolic blood pressure less than 105 mm Hg, most recent potassium < 5.1, any potassium > 5.5, most recent glomerular filtration rate < 30 (using MDRD equation), or a documented MRA allergy.

Where it is running

• University of Massachusetts — Boston, Massachusetts, United States
• NYU Langone Health — New York, New York, United States
• OhioHealth — Columbus, Ohio, United States
• University of Pennsylvania — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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