A Study of Telitacicept for the Treatment of Generalized Myasthenia Gravis (UPSTREAM MG)

Recruiting now · Phase 3 · Has a placebo group

Conditions studied: Generalized Myasthenia Gravis

In brief

The purpose of this study is to evaluate the efficacy and safety of telitacicept in the treatment of generalized myasthenia gravis.

Key facts

Study ID

NCT06456580

Run by

Vor Biopharma

People needed

180

Starts

2024-07-17

Expected to finish

2029-01-01

Last updated by the study team

2026-06-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• University of Southern California — Los Angeles, California, United States (enrolling)
• University of California Irvine — Orange, California, United States (enrolling)
• University of California San Francisco (UCSF) — San Francisco, California, United States (enrolling)
• SFM Clinical Research — Boca Raton, Florida, United States (enrolling)
• Allied Biomedical Research Institute (ABRI) — Miami, Florida, United States (enrolling)
• Medsol Clinical Research Center — Port Charlotte, Florida, United States (enrolling)
• University of South Florida Health (USF Health) — Tampa, Florida, United States (enrolling)
• Wellstar MCG Health Medical Center — Augusta, Georgia, United States (enrolling)
• Hospital Sisters Health System Medical — O'Fallon, Illinois, United States (enrolling)
• University of Kansas Medical Center — Kansas City, Kansas, United States (enrolling)
• University of Kentucky — Lexington, Kentucky, United States (enrolling)
• University of Louisville Physicians — Louisville, Kentucky, United States (enrolling)
• Neurology Center of New England — Foxborough, Massachusetts, United States (enrolling)
• Michigan State University Clinical Center — East Lansing, Michigan, United States (enrolling)
• Trinity Health - Grand Rapids Hospital — Grand Rapids, Michigan, United States (enrolling)
• UM Health Care - Neurology and Sleep Disorders Clinic — Columbia, Missouri, United States (enrolling)
• Hospital for Special Surgery — New York, New York, United States (enrolling)
• Mount Sinai Health System — New York, New York, United States (enrolling)
• Montefiore Medical Center — The Bronx, New York, United States (enrolling)
• University of North Carolina Hospitals - Neurology Clinic — Chapel Hill, North Carolina, United States (enrolling)
• University of Cincinnati Health Physicians - Clifton — Cincinnati, Ohio, United States (enrolling)
• Empower Clinical Research — Tigard, Oregon, United States (enrolling)
• University of Texas Southwestern Medical Center — Dallas, Texas, United States (enrolling)
• Houston Methodist Neurological Institute — Houston, Texas, United States (enrolling)
• HonorHealth Neurology - Bob Bové Neuroscience Institute — Scottsdale, Arizona, United States (enrolling)

Full record on ClinicalTrials.gov

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