Association Between Euploid Embryo Grade and Maternal Age

Stopped early

Conditions studied: Fertility

In brief

Background: Advanced maternal age (AMA) is associated with a reduction in live birth rate (LBR) after ART cycles. The main reason for this reduction is the lower number of oocytes aspirated, the number of developing embryos and the low number of euploid embryos available for transfer. The impact of age on success rates after the transfer of an euploid embryo has been a matter of discussion, with a recent meta-analysis showing a reduction in LBR after the transfer of an euploid blastocyst to women of AMA (1). There could be many reasons for this reduced LBR but they can be categorized into two broad categories - the uterus (including the mother's health) and the embryo (including the oocyte and the sperm). It is possible that factors associated with reduced embryo quality would manifest in a lower embryo grade.

Key facts

Study ID

NCT06454058

Run by

Inception Fertility Research Institute, LLC

People needed

502

Starts

2024-06-07

Expected to finish

2025-03-26

Last updated by the study team

2025-07-20

Who can join

Age: any. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Patients who have completed IVF egg retrieval with PGT-A testing at a fertility clinic in The Prelude Network (US clinics, excluding NYU)
• PGT biopsy was conducted in 2023,
• PGT biopsy was performed on blastocyst stage embryo,
• PGT-A result is euploid.

You may not qualify if…

• PGT-A result is mosaic,
• Embryos in which PGT-M was done and were found to be carriers of the mutation,
• Embryos in which PGT-SR was done and were found to be carriers of the structural rearrangement.

Where it is running

• Inception Fertility Research Institute, LLC — Houston, Texas, United States

Full record on ClinicalTrials.gov

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