Pulmonary Rehabilitation in the Chronically Critically Ill Patient

Recruiting now

Conditions studied: Rehabilitation, Chronic Critical Illness

In brief

The goal of this observational study is to learn about the population of chronically critical ill patients who refer to respiratory rehabilitation units. The main questions it aims to answer are: * what are the clinical and pathophysiological characteristics of the population of chronically critical ill patients who refer to respiratory rehabilitation units after hospital admission with the need for prolonged invasive mechanical ventilation via tracheostomy? * what is the response of this patient population to respiratory rehabilitation treatment in terms of functional recovery, weaning from invasive mechanical ventilation, weaning from tracheostomy tube, mortality and return to home? * are there any appreciable indices at admission and/or in the first period of hospitalization which may have a prognostic significance both on short-term objectives (weaning from invasive mechanical ventilation, weaning from the tracheostomy tube) and in the medium-long term (survival, state of health)? Participants will be subjected to a rehabilitation and weaning program consisting of: * physical therapy, * speech therapy, * nutritional assessment and therapy, * in subjects on invasive mechanical ventilation at admission a program of weaning and, if needed, shift from invasive to Non-Invasive Ventilation will be performed.

Key facts

Study ID

NCT06453421

Run by

Fondazione Don Carlo Gnocchi ETS

People needed

220

Starts

2023-02-10

Expected to finish

2029-08-10

Last updated by the study team

2025-03-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• age >18 years;
• episode of acute or acute-on-chronic respiratory failure with the need for prolonged invasive mechanical ventilation via tracheostomy

You may not qualify if…

• condition of clinical instability such as to make it necessary to transfer the patient to acute hospital within the first 7 days of hospitalization.

Where it is running

• IRCCS Fondazione Don Carlo Gnocchi ONLUS — Florence, Italy (enrolling)

Full record on ClinicalTrials.gov

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