Cellular and Molecular Biomarkers in Patients With Lichen Planus

Recruiting now · Not applicable

Conditions studied: Lichen Planus

In brief

Lichen planus (LP) is a chronic inflammatory disease of unknown aetiology, affecting the skin and mucous membranes, characterised by a CD8+ cytotoxic T-cell infiltrate, associated with epithelial cell death and disruption of the basement membrane zone. In previous work, T cell antigen receptor (TCR) repertoire studies were performed. In all patients tested, whether with erosive or non-erosive LP, unique nucleotide sequences, called clonotypes, have been identified. They appear during the process of TCR gene rearrangement. These clonotypes are specific for human papillomavirus (HPV) in blood and lesions, suggesting antigenic stimulation of these clonotypes by a viral epitope of HPV, which crosses with an epitope on keratinocytes. The diagnosis of LP is made on the basis of clinical and histological criteria, but in some patients and in some anatomical locations, the diagnosis is difficult to make and LP may be confused with other skin conditions.

Key facts

Study ID

NCT06451744

Run by

Institut Pasteur

People needed

70

Starts

2023-11-01

Expected to finish

2027-04-30

Last updated by the study team

2025-07-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subject coming at the time of diagnosis of the disease before any systemic treatment, or at the time of a progressive episode of the disease, without systemic treatment or after cessation of immunomodulatory or immunosuppressive treatment
• Ability to give their consent in writing
• Must understand spoken and written French
• Affiliated to the French social security or assimilated regimes

You may not qualify if…

• Dermatosis exclusively localised in the skin folds or on the face (risk of scarring from biopsies)

Where it is running

• CHU de Besançon — Besançon, France (enrolling)
• CHU Paris Seine-Saint-Denis- Hôpital Avicenne — Bobigny, France (enrolling)
• Centre Medical de l'Institut Pasteur — Paris, France (enrolling)
• Hôpital Saint-Louis — Paris, France (enrolling)
• Hôpital Robert Debré, CHU de Reims — Reims, France (enrolling)
• CHU de Rouen — Rouen, France (enrolling)

Full record on ClinicalTrials.gov

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