IndObufen Versus asPirin After Coronary Drug-eluting Stent implantaTION in Elderly Patients With Acute Coronary Syndrome
Recruiting now · Phase 4
Conditions studied: Coronary Artery Disease, Antiplatelet Drugs
In brief
The OPTION2 trial (randomized controlled trial of IndObufen versus asPirin after coronary drug-eluting stent implantaTION in elderly patients with acute coronary syndrome) was designed to compare the 1-year clinical efficacy and safety of indobufen-based dual antiplatelet therapy (DAPT) (indobufen 100mg bid plus ticagrelor 90mg bid) or conventional DAPT (aspirin 100mg qd plus ticagrelor 90mg bid) in acute coronary syndrome (ACS) patients aged over 65 years old undergoing coronary drug-eluting stent (DES) implantation.
Key facts
- Study ID
- NCT06451198
- Run by
- Shanghai Zhongshan Hospital
- People needed
- 2846
- Starts
- 2025-05-19
- Expected to finish
- 2028-12-31
- Last updated by the study team
- 2026-03-12
Who can join
Age: 65 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age over 65 years old
- Diagnosed with acute coronary syndrome (unstable angina/ non-ST elevation myocardial infarction/ ST elevation myocardial infarction)
- Treated with at least 1 DES implanted in the coronary lesion
- Receiving dual antiplatelet therapy (aspirin plus ticagrelor)
- Agree to attend the trial
You may not qualify if…
- Elective surgical procedure planned within 12 months
- Life expectancy ≤1 year
- Known allergy or intolerance to aspirin, ticagrelor or nonsteroidal anti-inflammatory drugs (NSAIDs)
- History of cerebral hemorrhage
- History of stroke in six months
- Active bleeding
- Known relevant hematological deviations
- Known, clinically important thrombocytopenia (i.e., <100*10\^9/L) or anemia (i.e., <90g/L)
- Active cancer
- Concomitant use of oral anticoagulants
- Active participation in another clinical study
- Other situations in which the investigator considers unsuitable to attend the study
Where it is running
- Zhongshan Hospital Fudan University — Shanghai, Shanghai Municipality, China (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.