Low-calorie Diet in Isolated Impaired Fasting Glucose

Withdrawn before enrolling · Not applicable

Conditions studied: Isolated Impaired Fasting Glucose

In brief

This study aims to evaluate the preliminary efficacy of a low-calorie diet (LCD) intervention in addressing the underlying pathophysiological abnormalities and improving fasting hyperglycemia among individuals with isolated impaired fasting glucose (i-IFG). Additionally, it seeks to assess the feasibility and acceptability of the LCD intervention.

Key facts

Study ID

NCT06451055

Run by

Emory University

People needed

0

Starts

2026-06-01

Expected to finish

2026-12-30

Last updated by the study team

2026-06-17

Who can join

Age: 35 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Aged 35 to 65 years
• Overweight (body mass index (BMI) ≥25 to <29 kg/m² or ≥23 to <29 kg/m² if Asian descent) or Obese (BMI ≥30 kg/m²)
• Physically inactive (<150 minutes per week of moderate-intensity physical activity or <75 minutes per week of vigorous-intensity physical activity)
• Prediabetes diagnosis or score ≥5 on the American Diabetes Association (ADA) risk tool

You may not qualify if…

• Diagnosed with type 1 or type 2 diabetes
• Cardiovascular disease (myocardial infarction, stroke, angina, heart failure, or other cardiac conditions)
• Chronic kidney disease
• Chronic liver disease (e.g., cirrhosis)
• Cancers
• Acute inflammatory bowel disease, irritable bowel syndrome, celiac disease, chronic pancreatitis, or other disorders potentially causing malabsorption
• Food allergies
• Participation in weight loss programs in the past six months
• Currently following a specific diet (e.g., ketogenic diet, Mediterranean diet)
• Participation in any exercise programs in the past six months
• Currently taking weight-loss medications or drugs known to affect glycemia (steroids and antipsychotics)
• Previous bariatric surgery or plan to have bariatric surgery during the study period
• Planning to relocate during the study period
• Intending to fast during the study period for religious or other reasons
• Pregnancy or planning to become pregnant during the study period
• Breastfeeding
• Non-English speaker

Where it is running

• Georgia Clinical & Translational Science Alliance (CTSA) Clinical Research Centers (GCRCs) — Atlanta, Georgia, United States

Full record on ClinicalTrials.gov

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