Evaluation of Multi-Cancer Early Detection Testing in a High-Risk Population: The INFORM Study

Recruiting now · Not applicable

Conditions studied: Cancer Predisposition Syndrome, Predisposition, Genetic

In brief

The purpose of this research study is to evaluate the possible benefits and harms of screening with an investigational blood test designed to detect many types of cancer early. The name of the screening blood test being studied is: -GRAIL Galleri test

Key facts

Study ID

NCT06450171

Run by

Dana-Farber Cancer Institute

People needed

1000

Starts

2024-09-27

Expected to finish

2028-01-31

Last updated by the study team

2026-01-20

Who can join

Age: 22 and older. Sex: any. Healthy volunteers: accepted.

You may not qualify if…

• Individuals diagnosed with invasive malignancy within 3 years of enrollment
• Have had a blood-based multi-cancer screening test within last year
• Individuals with evidence of symptomatic or active cancer requiring active therapeutic intervention at the time of participation (hormone therapy for breast/prostate cancer is considered acceptable and will not preclude participation)
• Individuals in Group 2 whose family history of cancer was the result of a germline mutation in a cancer predisposing gene and who have tested negative for that same familial germline mutation
• Individuals in Group 2 whose family history of cancer is sex-specific and who is a different sex than the proband with cancer (e.g., a male with a family history of endometrial or ovarian cancer would not be eligible)
• Individuals in process of being evaluated for clinical suspicion of cancer
• Individuals who have undergone a cancer risk-reducing surgery for hereditary cancer risk (e.g., mastectomy)

Where it is running

• Dana-Farber Cancer Institute — Boston, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.