Multimodal Image Analysis and Guidance of Neuromodulation for Trauma-Related Symptoms

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Posttraumatic Stress Disorder

In brief

MAGNETS is a prospective, randomized, parallel-design, sham-controlled clinical trial of accelerated, functional magnetic resonance imaging (fMRI)-guided intermittent theta burst stimulation (iTBS) to the right dorsolateral prefrontal cortex (dlPFC) for chronic symptoms of posttraumatic stress disorder (PTSD) in a comorbid Veteran population.

Key facts

Study ID

NCT06449326

Run by

University of New Mexico

People needed

64

Starts

2024-06-01

Expected to finish

2027-10-01

Last updated by the study team

2026-07-06

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Veterans will be enrolled in this study if they:
• are aged 18-80;
• have a documented diagnosis of PTSD with evidence of ongoing symptoms as demonstrated by score of "31" or higher on the PCL-5, a measure of posttraumatic stress symptoms;
• are fluent in English (as the neuropsychological testing tools used are only available in English) and
• have been on stable doses of psychotropic medications for the past month.

You may not qualify if…

• Veterans will be excluded from participation in this study if there is:
• a prior history of other neurological disease beyond mild TBI, as determined by VA/DoD criteria for TBI severity;
• any history of seizures beyond immediate posttraumatic seizure or childhood febrile seizure, so as to reduce risk of exacerbation of epilepsy or other neurological symptoms;
• history of a psychotic disorder, such as schizophrenia or bipolar disorder, so as to reduce risk of psychiatric decompensation;
• active substance/alcohol dependence without ongoing treatment, to reduce confounding effects on diagnosis and brain imaging;
• presence of any implanted electrical device (e.g., pacemaker), to reduce risk of device malfunction from rTMS;
• recent medical hospitalization (within four weeks), to reduce risk of medical decompensation during the study;
• any condition that would prevent the subject from completing the protocol;
• appointment of a legal representative or inability to provide informed consent, to avoid coercion of a vulnerable population;
• any ongoing litigation related to PTSD, TBI, disability determination, or service connection, to prevent interference with legal proceedings;
• any contraindication to MRI;
• pregnant women, so as to prevent complications;
• membership in an identified vulnerable population, including minors and prisoners, so as to prevent coercion;
• Cognitively impaired adults who lack capacity to consent.

Where it is running

• UNM Center for Psychiatric Research — Albuquerque, New Mexico, United States (enrolling)
• New Mexico VA Health Care System — Albuquerque, New Mexico, United States (enrolling)

Full record on ClinicalTrials.gov

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