Mindfulness-based Neurofeedback to Augment Psychotherapy for Adults With Borderline Personality Disorder

Recruiting now · Phase 2

Conditions studied: Borderline Personality Disorder

In brief

The purpose of this study is to test the ability of mindfulness-based real time functional magnetic resonance imaging (fMRI) neurofeedback (mbNF) to increase the benefits of evidence-based psychotherapy for adults with Borderline Personality Disorder (BPD).

Key facts

Study ID

NCT06446765

Run by

Yale University

People needed

150

Starts

2025-03-13

Expected to finish

2026-10-30

Last updated by the study team

2026-06-09

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• age 18-60,
• be able to provide written informed consent,
• meet criteria for BPD on semi-structured clinical interview,
• able to plan to keep any prescribed medications and psychotherapy constant during the study
• fluent in English.

You may not qualify if…

• current DBT psychotherapy outside the study
• lifetime primary psychotic disorder
• manic episode in the last one year
• developmental disorder (e.g. autism)
• history of learning disorder
• severe substance use disorder in the last 3 months
• active suicidal ideation with intent or plan in the past 3 months
• history of major medical or neurologic disorder
• MRI contraindications, including pregnancy
• poor performance on reading task (WRAT > 11 errors)
• newly prescribed medications in the past 8 weeks
• daytime sedating medications (e.g. benzodiazepines, opiates, sedating neuroleptics)
• any scheduled daily benzodiazepines
• change in psychotherapy type or frequency in the past 12 weeks.
• At the discretion of the study PI
• Eligibility will be determined by study personnel.

Where it is running

• Connecticut Mental Health Center — New Haven, Connecticut, United States (enrolling)

Full record on ClinicalTrials.gov

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