Transient Receptor Potential Channels

Enrolling by invitation · Early Phase 1

Conditions studied: Aging

In brief

Neurovascular signaling in the skin associated with stimulation of the transient receptor potential (TRP) channels. These channels are stimulated by both temperature and naturally occurring bioactive agents found in mint, chili peppers, garlic, etc. The aim of the study is to examine how topically applied TRP channel agonists including menthol, capsaicin and camphor impact neurovascular responses in the skin.

Key facts

Study ID

NCT06444594

Run by

Penn State University

People needed

45

Starts

2024-07-17

Expected to finish

2027-12-31

Last updated by the study team

2026-07-27

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 18-85 years old.
• Women will not be pregnant and/or breastfeeding.

You may not qualify if…

• Currently pregnant or breastfeeding
• Nicotine use (e.g., smoking, chewing tobacco etc.), quantified as more than 100 cigarettes or cigars in a lifetime)
• Known skin allergies or current rash, skin disease, disorders of pigmentation
• Diabetes
• Body mass index >35kg*m-2
• Using calcium channel blockers
• Raynaud's syndrome
• Allergy or hypersensitivity to menthol, camphor, capsaicin or adhesive
• Regular use (defined as greater than once a week) of topical analgesics that contain menthol, camphor or capsaicin

Where it is running

• Noll Laboratory — University Park, Pennsylvania, United States

Full record on ClinicalTrials.gov

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