EXtubation Related Complications - the EXTUBE Study (EXTUBE)

Recruiting now

Conditions studied: Extubation

In brief

EXTUBE is an international, multicentre, prospective cohort study evaluating the incidence, risk factors, and outcomes of extubation-related complications and describing clinical practices related to extubation after general anesthesia or after critical illness in the operating room (OR), out of OR anesthesia location or intensive care unit (ICU).

Key facts

Study ID

NCT06442930

Run by

University Health Network, Toronto

People needed

3000

Starts

2025-04-14

Expected to finish

2027-12-01

Last updated by the study team

2026-07-21

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients (≥18 years old)
• Undergoing extubation of an endotracheal tube (including index extubation and re-extubations) after general anesthesia in the OR, out of OR anesthesia location or ICU
• Undergoing extubation during the specified enrollment window

You may not qualify if…

• Patients will be excluded if the extubation is performed in the context of withdrawal of life support measures,
• Patients will be excluded if the extubation is performed for tracheostomy decannulation
• For each patient who is not included, reasons for exclusion will be reported.

Where it is running

• University Health Network - Toronto General Hospital — Toronto, Ontario, Canada (enrolling)
• University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
• University of Florida — Gainesville, Florida, United States
• The University of Chicago — Chicago, Illinois, United States
• Oregon Health & Science University — Portland, Oregon, United States
• The University of Texas Health Science Center — Houston, Texas, United States
• Royal North Shore Hospital — Sydney, New South Wales, Australia
• The Northern Hospital — Melbourne, Victoria, Australia
• Austin Hospital — Melbourne, Victoria, Australia
• Eastern Health - Box Hill Hospital — Melbourne, Victoria, Australia
• Eastern Health - Maroondah Hospital — Melbourne, Victoria, Australia
• Eastern Health - Angliss Hospital — Melbourne, Victoria, Australia
• Surrey Memorial Hospital — Surrey, British Columbia, Canada
• The Moncton Hospital — Moncton, New Brunswick, Canada
• Sunnybrook Hospital — North York, Ontario, Canada
• Niagara Health - Marotta Family Hospital — Saint Catharines, Ontario, Canada
• St. Michael's Hospital — Toronto, Ontario, Canada
• Mount Sinai Hospital — Toronto, Ontario, Canada
• University Health Network - Toronto Western Hospital — Toronto, Ontario, Canada
• Centre hospitalier de l'Université de Montréal (CHUM) — Montreal, Quebec, Canada
• Hospital Internacional de Colombia — Piedecuesta, Colombia
• Mayo University Hospital — Castlebar, Ireland
• Cork University Hospital — Cork, Ireland
• Mater Misericordiae University Hospital — Dublin, Ireland
• Galway University Hospitals — Galway, Ireland

Full record on ClinicalTrials.gov

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