Understanding the Variation of Modern Endoscopic Ultrasound Use in Patients With Oesophageal Cancer (VALUE)
Recruiting now
Conditions studied: Oesophageal Cancer
In brief
This is an observational trial that will look at patients undergoing endoscopic ultrasound (EUS) in patients with oesophageal cancer and to determine the proportion of cases in which EUS changes disease management in these patients.
Key facts
- Study ID
- NCT06440174
- Run by
- University Hospital Southampton NHS Foundation Trust
- People needed
- 160
- Starts
- 2024-06-27
- Expected to finish
- 2026-12-31
- Last updated by the study team
- 2026-04-30
Who can join
Age: 16 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients aged 16 or above with first diagnosis of biopsy-confirmed oesophageal cancer.
- Referred for EUS examination as part of standard of care investigations.
- Tumour location in the oesophagus, or gastro-oesophageal junction (Siewert types I-III)
- MDT decision that patient is potentially curable with radical treatment (e.g., endoscopic treatment, surgery +/- neoadjuvant therapy, or definitive chemoradiotherapy)
- Prior staging with CT and PET-CT
- Eastern Cooperative Oncology Group (ECOG) performance status 0-2
- Clinical staging of T1-T4, N0-N3, M0 disease
- Adenocarcinoma or squamous cell carcinoma (SCC) histopathological cell type
You may not qualify if…
- Recurrent or residual disease
- Distant metastatic disease detected before EUS.
- Previous oesophagectomy or oesophageal radiotherapy
- Unable to undergo EUS examination.
- Concurrent malignancy e.g., second primary tumour
- Other histopathological cell type
Where it is running
- Royal Cornwall Hospital — Truro, United Kingdom (enrolling)
- Cwm Taf UHB — Abercynon, United Kingdom (enrolling)
- Cambridge University NHS Foundation Trust — Cambridge, United Kingdom (enrolling)
- Cardiff and Vale UHB — Cardiff, United Kingdom (enrolling)
- Velindre University NHS Trust — Cardiff, United Kingdom (enrolling)
- Glasgow Royal Infirmary — Glasgow, United Kingdom (enrolling)
- Castle Hill Hospital — Hull, United Kingdom (enrolling)
- Guy's and St Thomas' NHS Foundation Trust — London, United Kingdom (enrolling)
- Imperial College Healthcare NHS Trust — London, United Kingdom (enrolling)
- Queen's Medical Centre, Nottingham — Nottingham, United Kingdom (enrolling)
- Salford Royal Hospital — Salford, United Kingdom (enrolling)
- University Hospital Southampton — Southampton, United Kingdom (enrolling)
- Singleton Hospital, Swansea — Swansea, United Kingdom (enrolling)
- Royal Bournemouth Hospital — Bournemouth, United Kingdom
Full record on ClinicalTrials.gov
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