Relationship Between Circulating Sclerostin and Bone Lesions in Patients With Mastocytosis

Recruiting now

Conditions studied: Mastocytosis, Bones

In brief

Mastocytosis is very rare and highly heterogeneous group of disorders, characterized by the accumulation of clonal mast cells which can infiltrate several organs and tissues. Bones are the most frequent localization of systemic mastocytosis. The aim of our research was to explain the potential role of sclerostin in the pathogenesis of bone disease in mastocytosis.

Key facts

Study ID

NCT06440148

Run by

Medical University of Lublin

People needed

50

Starts

2019-09-01

Expected to finish

2026-12-31

Last updated by the study team

2024-06-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age > 18 years
• Mastocytosis defined according to WHO criteria
• Known KIT mutation status

You may not qualify if…

• History of organ transplant
• Inability to give informed consent
• Pregnancy, Breastfeeding
• Vulnerable Patient, defined as: patient with another uncontrolled severe disease; patient under juridical protection

Where it is running

• Department of Hematooncology and Bone Marrow Transplantation — Lublin, Lublin Voivodeship, Poland (enrolling)

Full record on ClinicalTrials.gov

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