Effects of Nasal Ventilation on Cerebral and Pulmonary Function in Orally Intubated Patients
Recruiting now
Conditions studied: Hypoxemic Acute Respiratory Failure
In brief
The passage of air through the nasal cavity generates rhythmic oscillations transmitted by the olfactory bulb to the brain, which induces cerebral activation in functional areas and is associated with better cognitive performance compared to oral breathing. Consequently, the abolition of nasal ventilation in patients intubated via the orotracheal route could have deleterious effects on brain activity. Besides the loss of olfaction, the abolition of nasal ventilation could affect brain activity and respiratory control, consequently altering regional pulmonary ventilation. The hypothesis of the study is that nasal ventilation through the passage of humidified nasal airflow in patients intubated via the orotracheal route would be associated with modulation of cerebral electrical activity and tissue oxygenation and a modification of regional pulmonary ventilation.
Key facts
- Study ID
- NCT06438302
- Run by
- Assistance Publique - Hôpitaux de Paris
- People needed
- 22
- Starts
- 2025-01-31
- Expected to finish
- 2028-02-01
- Last updated by the study team
- 2025-12-03
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥ 18 years old
- Hypoxemic acute respiratory failure
- Intubation and mechanical ventilation since less than 4 days
- PaO2/FiO2 ratio less than 200
- RASS<-4
- Consent obtained from next of kin
- Patient with health insurance
You may not qualify if…
- Central nervous system diseases (stroke, MS, epilepsy)
- Psychiatric illnesses (psychosis, depression) (indicated on patient's medical record)
- Hemodynamic instability (noradrenalin>2mg/h)
- Patient on AME
- Patients under legal protection (guardianship/curators)
- Pregnant or breast-feeding women
Where it is running
- Service de Médecine Intensive Réanimation - Hôpital Pitié -Salpêtrière — Paris, France (enrolling)
Full record on ClinicalTrials.gov
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