Early Switch from Controlled to Assisted Ventilation
Recruiting now · Not applicable
Conditions studied: Acute Hypoxemic Respiratory Failure, Mechanical Ventilation
In brief
The goal of this physiological intervention study is to unravel the (patho)physiological mechanisms and potential clinical benefits of a pre-specified early switch from controlled to assisted ventilation in mechanically ventilated adult patients with acute hypoxemic respiratory failure (PaO2/FiO2 ratio \< 200 mmHg). The intervention is that participants will be switched from controlled to assisted ventilation when PaO2/FiO2 ratio \> 200 mmHg. The primary endpoint is the change in regional lung stress (as derived by electrical impedance tomography) when switching from controlled to assisted ventilation and until a successful or failed switch.
Key facts
- Study ID
- NCT06438198
- Run by
- Erasmus Medical Center
- People needed
- 20
- Starts
- 2024-09-15
- Expected to finish
- 2026-05-01
- Last updated by the study team
- 2024-10-18
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 18 years old
- Written informed consent from a legal representative
- Mechanical ventilation via an endotracheal tube
- Acute hypoxemic respiratory failure with PaO2/FiO2 ratio < 200 mmHg
- Under continuous sedation with or without paralysis
You may not qualify if…
- Expected mechanical ventilation duration of <48 hours
- Pure chronic obstructive pulmonary disease exacerbation
- Pre-existent respiratory muscle disease
- Contraindication to EIT monitoring (as per clinical protocol, e.g. pacemaker, burns or thoracic wounds limiting electrode placement)
- Contra-indications to oesophageal manometry (as per clinical protocol, e.g., recent oesophageal surgery, oesophageal varices, severe bleeding disorders)
- Known pregnancy
- Anticipating withdrawal of life support and/or shift to palliation as the goal of care
Where it is running
- Erasmus MC — Rotterdam, Netherlands (enrolling)
Full record on ClinicalTrials.gov
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