Resistance Exercise Plus Vinegar Ingestion on Biomarkers in Healthy Adults
Completed · Not applicable
Conditions studied: LPS, Mood Disorders, Cognitive Change
In brief
Given its capacity to stimulate exercise-induced neuroplasticity at lower doses compared to aerobic exercise, resistance exercise has become the top-recommended rehabilitation approach for individuals with neurocognitive impairments. Despite a large body of evidence supporting its application in the context of cognition, little work has been done to investigate the role of resistance exercise in modifying the structure and function of the microbiota-gut-brain axis. Likewise, despite a general understanding of the benefits of short chain fatty acids such as acetate for the gut-brain axis, the impact of exogenous acetic acid has not been sufficiently examined in the context of the intestinal barrier. While self-reported mood disturbance responds favorably to vinegar ingestion, it is currently unknown if these effects are also associated with changes in intestinal permeability.
Key facts
- Study ID
- NCT06437405
- Run by
- Arizona State University
- People needed
- 29
- Starts
- 2024-05-22
- Expected to finish
- 2025-02-15
- Last updated by the study team
- 2025-04-09
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- premenopausal (for those assigned female at birth)
- willing and able to participate in moderate to vigorous exercise as determined by the ACSM Health/Fitness Facility Preparticipation Screening Questionnaire
- sedentary (defined as a score <14 on the Godin-Shepard Leisure Time Physical Activity Questionnaire (GSLTQ))
- equipped with access to a complete gym
- available for all lab visits (at weeks 0, 3, 9, and 15)
You may not qualify if…
- antibiotic use within the past three months
- prebiotic, probiotic, or high-dose antioxidant supplementation within the past month
- regular engagement in moderate to vigorous exercise
- following a vegetarian diet
- presence of any medical/psychiatric disease
- presence of any gastrointestinal disorder such as irritable bowel syndrome, inflammatory bowel disease, Crohn's disease, diverticulitis/diverticulosis, etc.
- actively pregnant or breastfeeding
Where it is running
- 850 PBC — Phoenix, Arizona, United States
Full record on ClinicalTrials.gov
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