A Study About Modified RNA Vaccines Against Influenza in Healthy Adults
Completed · Phase 1/Phase 2
Conditions studied: Influenza, Human
In brief
The purpose of this study is to learn if modified RNA (modRNA) vaccines for the prevention of influenza are: * safe; and * how these vaccines produce an immune response in generally healthy adults. Immune response is the way the body protects itself against things it sees as harmful or foreign. RNA (also called ribonucleic acid) is one of two types of nucleic acid made by cells. RNA contains information that has been copied from DNA (the other type of nucleic acid). Cells make several different forms of RNA, and each form has a specific job in the cell. Many forms of RNA have functions related to making proteins. RNA is also the genetic material of some viruses instead of DNA. RNA can be made in the laboratory and used in research studies. Also called ribonucleic acid. Influenza is term used for flu illness. It is an infection caused by a virus that affects your mouth, nose, and throat. The study is seeking for participants who: * are at least 18 years of age * have not received an influenza vaccine within the last 6 months * are generally healthy This study will be divided into three sub-studies: Substudy A (SSA), Substudy B (SSB), and Substudy C (SSC). All participants, regardless of sub-study, will receive 1 dose of either of the following vaccines as an injection into their arm: * 1 of the modRNA influenza vaccines that is being studied; or * an approved influenza vaccine approved for use in their respective age group. Participants will be involved in this study for about 6 months. During this time, participants will have at least 3 clinic visits.
Key facts
- Study ID
- NCT06436703
- Run by
- Pfizer
- People needed
- 1202
- Starts
- 2024-05-23
- Expected to finish
- 2025-02-05
- Last updated by the study team
- 2026-06-12
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
Where it is running
- AMR Clinical — Mobile, Alabama, United States
- Headlands Research - Scottsdale — Scottsdale, Arizona, United States
- Anaheim Clinical Trials, LLC — Anaheim, California, United States
- Orange County Research Center — Lake Forest, California, United States
- Artemis Institute for Clinical Research — San Diego, California, United States
- Diablo Clinical Research, Inc. — Walnut Creek, California, United States
- Clinical Research Consulting — Milford, Connecticut, United States
- Indago Research & Health Center, Inc — Hialeah, Florida, United States
- Research Centers of America ( Hollywood ) — Hollywood, Florida, United States
- Research Centers of America — Hollywood, Florida, United States
- Palm Springs Community Health Center — Miami Lakes, Florida, United States
- Clinical Neuroscience Solutions, Inc. — Orlando, Florida, United States
- Headlands Research Orlando — Orlando, Florida, United States
- Qps-Mra, Llc — South Miami, Florida, United States
- East-West Medical Research Institute — Honolulu, Hawaii, United States
- Alliance for Multispecialty Research, LLC — New Orleans, Louisiana, United States
- Prism Research LLC dba Nucleus Network — Saint Paul, Minnesota, United States
- Clinical Research Professionals — Chesterfield, Missouri, United States
- Alliance for Multispecialty Research, LLC — Kansas City, Missouri, United States
- Rochester Clinical Research, LLC — Rochester, New York, United States
- Duke Vaccine and Trials Unit — Durham, North Carolina, United States
- M3 Wake Research, Inc. — Raleigh, North Carolina, United States
- DM Clinical Research - Philadelphia — Philadelphia, Pennsylvania, United States
- Headlands Horizons LLC — Brownsville, Texas, United States
- SMS Clinical Research — Mesquite, Texas, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.