A Study of the Effects of Camoteskimab in Adults With Moderate to Severe Atopic Dermatitis

Completed · Phase 2 · Has a placebo group

Conditions studied: Atopic Dermatitis, Atopic, Dermatitis, Dermatologic Disease, Eczema, Eczema Atopic Dermatitis, Eczema, Atopic

In brief

This is a Phase 2a, multicenter, randomized, double-blind, placebo-controlled study with an open-label extension to evaluate the efficacy and safety of camoteskimab in adults with moderate to severe AD.

Key facts

Study ID: NCT06436183
Run by: Apollo Therapeutics Ltd
People needed: 62
Starts: 2024-05-01
Expected to finish: 2025-08-12
Last updated by the study team: 2025-09-18

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Participants must be 18-75 years of age inclusive, at the time of signing the informed consent.
Chronic AD for at least 1 year.
Participants with moderate to severe AD defined by:
Investigator global assessment (IGA) score of ≥ 3 (on a scale of 0 to 4, in which three is moderate and four is severe) at Baseline.
AD involvement of ≥ 10% body surface area (BSA) at Baseline.
EASI score of ≥ 12 at Baseline.
Pruritus numerical rating scale (NRS) ≥ 4 at Baseline.
Participants who are candidates for systemic therapy, defined as inadequate response to treatment with topical medications, or for whom topical treatments are otherwise medically inadvisable.
Contraceptive use should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies.
Female participants:
Sexually active females of childbearing potential must agree to use two forms of accepted methods of highly effective forms of contraception during the course of the study and for 3 months after their last dose of study drug. Effective birth control includes:
IUD plus one barrier method.
Stable doses of hormonal contraception for at least 3 months (e.g., oral, injectable, implant, transdermal) plus one barrier method.
2 barrier methods. Effective barrier methods are male or female condoms, diaphragms, and spermicides (creams or gels that contain a chemical to kill sperm); or
A vasectomized partner*.
Male participants:
Sexually active male participants and males and who are partners of females of childbearing potential agree to use two forms of contraception as above and to not donate sperm or try to conceive during the treatment period and for at least 3 months after the last dose of study drug.
Participant provides signed informed consent.

You may not qualify if…

Participant has history of use of more than two (2) prior systemic therapies for AD (e.g.
biologics or JAKi) and who used any of these medications as follows:
Dupilumab, tralokinumab, lebrikizumab within 8 weeks prior to Baseline.
Systemic JAKi within 4 weeks prior to Baseline.
TCS, TCI, topical phosphodiesterase-4 (PDE4) inhibitors, and topical JAKi within 7 days prior to enrollment (at Baseline) or more than five half-lives whichever is longer.
Participant has a current diagnosis of other active skin disease (e.g., psoriasis or lupus erythematosus) or skin infection (bacterial, fungal, or viral) that may affect the evaluation of AD or would interfere with the study assessments.
Participant has a severe comorbidity that may require systemic steroids therapy or other interventions or requires active frequent monitoring (e.g., unstable chronic asthma).
Any clinically significant abnormalities in rhythm, conduction or morphology of the resting electrocardiogram (ECG) and any clinically significant abnormalities in the 12- lead ECG as considered by the perfusion index that may interfere with the interpretation of QTc interval changes.
Participant has AD involving ocular symptoms, or blepharitis, conjunctivitis, or keratitis diagnosed within the last 60 days prior to the screening visit, requiring chronic ocular corticosteroid treatment.
Participant has severe or uncontrolled seasonal or allergic rhinitis, asthma or any other non-AD disease as judged by the Investigator. Participants with seasonal or allergic rhinitis, asthma or any other non-AD disease requiring use of intranasal or inhaled corticosteroid that is stable and well-controlled are not excluded.
Active human immunodeficiency virus (HIV): confirmed positive anti-HIV antibody (HIV Ab) test; Active hepatitis B virus (HBV): confirmed hepatitis B surface antigen (HBs Ag) positive (+) or hepatitis B core antibody (HBc Ab) positive (+); Active hepatitis C virus (HCV): Confirmed hepatitis C antibody positive (+); evidence of active or latent TB
Diagnosed with a malignancy within 5 years of enrollment (suspected malignancy should be ruled out by blood or tissue biopsy, as applicable) with the exception of
Completely resected basal call or squamous cell carcinoma of the skin.
Carcinoma in situ of the cervix.
Has had previous exposure to anti-IL-18 therapy.
Treatment with any investigational agent, or any investigational device or procedure, within 28 days (or 5 half- lives, whichever is greater) of screening.
Has any of the following laboratory findings
Glomerular filtration rate (GFR) < 30 mL/min/1.73 m2.
Hemoglobin ≤8 g/dL.
Neutrophils ≤1,500/μL.
Platelets ≤75,000/μL.

Where it is running

Medical Dermatology Specialists, PC/US Dermatology Partners — Phoenix, Arizona, United States
California Dermatology & Clinical Research Institute — Encinitas, California, United States
First OC Dermatology Research, Inc. — Fountain Valley, California, United States
Center for Dermatology Clinical Research, Inc. — Fremont, California, United States
California Allergy and Asthma Medical Group — Los Angeles, California, United States
University of California Los Angeles Dermatology — Los Angeles, California, United States
Amicis Research Center (Northridge) — Northridge, California, United States
Cura Clinical Research — Oxnard, California, United States
VASDHS - Veterans Affairs San Diego Medical Center — San Diego, California, United States
Clinical Sciences Institute — Santa Monica, California, United States
Renaissance Research and Medical Group — Cape Coral, Florida, United States
D&H National Research Centers, Inc. — Miami, Florida, United States
Avita Clinical Research - Dermatology — Tampa, Florida, United States
Sneeze, Wheeze & Itch Associates, LLC — Normal, Illinois, United States
Dawes Fretzin Clinical Research — Indianapolis, Indiana, United States
Skin Sciences, PLLC — Louisville, Kentucky, United States
Owensboro Dermatology Associates — Owensboro, Kentucky, United States
Revival Research Institute — Troy, Michigan, United States
Somerset Skin Centre — Troy, Michigan, United States
Michigan Dermatology Institute — Waterford, Michigan, United States
Advanced Dermatology and Skin Cancer Center - Saint Joseph — Saint Joseph, Missouri, United States
Skin Specialists PC — Omaha, Nebraska, United States
M3 Wake Research, Inc. — Raleigh, North Carolina, United States
ObjectiveHealth-The Skin Surgery Center for Clinical Research — Winston-Salem, North Carolina, United States
Central Sooner Research — Oklahoma City, Oklahoma, United States

Full record on ClinicalTrials.gov

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