Understanding the Efficacy of Dietary Supplement on Fungal Mycobiota in Healthy Volunteers: A Pilot Study

Recruiting now · Phase 4

Conditions studied: Gut Microbiome, Gut Health, Dietary Supplement, L-Phenylalanine, Phenylpropionic Acid

In brief

The purpose of this study is to explore how the dietary supplement L-Phenylalanine affects the production of the metabolite phenylpropionic acid (PPA) and changes fungal populations of the gut microbiome.

Key facts

Study ID

NCT06433310

Run by

Weill Medical College of Cornell University

People needed

20

Starts

2024-10-17

Expected to finish

2027-12-31

Last updated by the study team

2026-06-26

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Male or female adults over the age of 18 years

You may not qualify if…

• History of a diagnosis of any gastrointestinal condition, such as inflammatory bowel syndrome or disease
• Antibiotic usage within the past two weeks
• Antifungal usage within the past month
• Allergy to L-Phenylalanine or individuals with phenylketonuria (PKU)
• Adults taking medications known to interact with L-phenylalanine supplements, such as Monoamine Oxidase Inhibitors (MOAI), L-DOPA, and some antipsychotic drugs (complete and extensive drug list will be provided to interested participants during screening)
• Pregnant or nursing women

Where it is running

• Belfer Research Building — New York, New York, United States (enrolling)

Full record on ClinicalTrials.gov

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