A Study of Brepocitinib in Adults With Active, Non-Infectious, Non-Anterior Uveitis

Running, not enrolling · Phase 3 · Has a placebo group

Conditions studied: Uveitis, Posterior, Uveitis, Intermediate, Uveitis

In brief

The purpose of this study is to determine the safety and efficacy of brepocitinib in participants with active, non-anterior (intermediate, posterior, or pan) non-infectious uveitis (NIU).

Key facts

Study ID

NCT06431373

Run by

Priovant Therapeutics, Inc.

People needed

371

Starts

2024-09-11

Expected to finish

2028-02-01

Last updated by the study team

2026-01-12

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult subjects (18-75 years old)
• Diagnosis of non-infectious uveitis (intermediate uveitis, posterior uveitis, or panuveitis)
• Active uveitic disease in at least 1 eye
• Weight > 40 kg with a body mass index ≤ 40 kg/m2

You may not qualify if…

• Has confirmed or suspected current diagnosis of infectious uveitis History of or have:
• Lymphoproliferative disorder
• active malignancy
• cancer within 5 years prior to screening (exceptions for basal cell carcinoma, squamous cell carcinoma, ductal carcinoma in situ of the breast, carcinoma in situ of the uterine cervix, or thyroid carcinoma.)
• thrombosis or cerebrovascular ischemic event disease within the last 12 months
• a high risk for herpes zoster reactivation
• active or recent infections

Where it is running

• Clinical Trial Site — Phoenix, Arizona, United States
• Clinical Trial Site — Bakersfield, California, United States
• Clinical Trial Site — Beverly Hills, California, United States
• Clinical Trial Site — Fullerton, California, United States
• Clinical Trial Site — Irvine, California, United States
• Clinical Trial Site — La Jolla, California, United States
• Clinical Trial Site — Los Angeles, California, United States
• Clinical Trial Site — Los Angeles, California, United States
• Clinical Trial Site — Modesto, California, United States
• Clinical Trial Site — Sacramento, California, United States
• Clinical Trial Site — Aurora, Colorado, United States
• Clinical Trial Site — Denver, Colorado, United States
• Clinical Trial Site — Fort Lauderdale, Florida, United States
• Clinical Trial Site — St. Petersburg, Florida, United States
• Clinical Trial Site — Chicago, Illinois, United States
• Clinical Trial Site — Oak Park, Illinois, United States
• Clinical Trial Site — Carmel, Indiana, United States
• Clinical Trial Site — Prairie Village, Kansas, United States
• Clinical Trial Site — Baltimore, Maryland, United States
• Clinical Trial Site — Boston, Massachusetts, United States
• Clinical Trial Site — Waltham, Massachusetts, United States
• Clinical Trial Site — Ann Arbor, Michigan, United States
• Clinical Trial Site — Detroit, Michigan, United States
• Clinical Trial Site — Detroit, Michigan, United States
• Clinical Trial Site — Phoenix, Arizona, United States

Full record on ClinicalTrials.gov

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