Hemodynamic Impact of the Administration of PAracetamol in Patients Hospitalized in the Intensive Resuscitation Medicine Department [PAREA]

Recruiting now · Not applicable

Conditions studied: Intensive Care Unit Syndrome

In brief

Paracetamol is commonly used in case of pain or fever. Few previously clinical studies has highlighted an arterial hypotension linked to intravenous administration of paracetamol. Currently, fewer data are available on the link of intravenous administration of paracetamol and effects on arterial tension. The aim of this study is to describe the frequency of occurrence of significative arterial hypotension within one hour following intravenous or per os administration of paracetamol . Other factors who can be associated to occurence of significative arterial hypotension will be also observe (for example age, weight, pain, vasopressor dosage or sedative...)

Key facts

Study ID

NCT06430697

Run by

Centre Hospitalier Universitaire de Nice

People needed

200

Starts

2025-02-03

Expected to finish

2028-09-01

Last updated by the study team

2026-05-26

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Inclusion:
• 18 years of age or older
• Patient with arterial catheter
• Indication of paracetamol's administration by the patient's attending practitioner.
• No opposition to patient or support person participation in the study if the patient is unable to participate

You may not qualify if…

• No Social Security Patient
• Pregnant or nursing patient.
• Patient with a legal protection measure
• Hypersensitivity and/or allergy to paracetamol.
• Contraindication to the use of paracetamol.
• Patient opposition to health data collection.

Where it is running

• CHU de NICE ARCHET — Nice, France (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.