Personalized Ventilation Based on Ventilation-perfusion Mismatch and Lung Recruitability

Recruiting now

Conditions studied: Respiratory Distress Syndrome, Positive-Pressure Respiration, Mechanical Ventilation

In brief

This observational study will explore the effects of PEEP and position on regional lung ventilation-perfusion mismatch by electrical impedance tomography (EIT) in moderate-to-severe ARDS patients with different lung recruitability.

Key facts

Study ID

NCT06430554

Run by

Zhongda Hospital

People needed

40

Starts

2024-06-08

Expected to finish

2026-06-30

Last updated by the study team

2026-02-03

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• age ≥18 years
• Moderate-to-severe ARDS as per the 2023 ESICM definition
• Undergoing invasive mechanical ventilation
• Planned prone position based on the attending physicians' decisions
• Signed informed consent

You may not qualify if…

• age ≥85 years
• Pregnancy
• Severe hemodynamic instability (> 30% increase in vasopressors in the last 6 hours or norepinephrine > 0.5 µg/kg/min)
• Clinically suspected elevated intracranial pressure (>18 mm Hg)
• Bronchopleural fistula
• Contraindication to EIT monitoring (e.g. burns, pacemaker, thoracic wounds limiting electrode belt placement)
• Severe hypernatremia (>170mmol/L)
• Re-admission of patients already enrolled in this study, or patients who are participating in other studies

Where it is running

• Zhongda Hospital, Southeast University — Nanjing, Jiangsu, China (enrolling)

Full record on ClinicalTrials.gov

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