Longitudinal Study of Gene Expression in the Human Placenta During First-trimester and Full-term Pregnancy at the Single Cell Level

Recruiting now

Conditions studied: Pregnancy Related

In brief

The single nucleus RNA-seq approach allows the placental transcriptome to be analyzed from nuclei, thus preserving the integrity of placental syncytium. This approach is feasible on small fragments of villi and offers for the first time the possibility to consider the characterization of gene expression within the structural unit of the human placenta during pregnancy (at the 1st trimester and childbirth)

Key facts

Study ID

NCT06427408

Run by

Assistance Publique - Hôpitaux de Paris

People needed

100

Starts

2026-03-25

Expected to finish

2029-02-01

Last updated by the study team

2026-04-03

Who can join

Age: 18 and older, up to 50. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 to 50
• Progressive monofoetal pregnancy between 11 and 15 weeks of amenorrhea
• Patient with prenatal medical indication and requesting chorionic villus biopsy with cytogenetic analysis or molecular genetics
• Patient scheduled for delivery at Port-Royal Maternity Hospital

You may not qualify if…

• Minor patient
• Multiple pregnancy
• Patient's objection
• Without health insurance
• Patient under guardianship or curatorship

Where it is running

• Maternité Port-Royal, Cochin hospital — Paris, IDF, France (enrolling)

Full record on ClinicalTrials.gov

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