Pediatric Antibiotic Dosing in Extracorporal Membrane Oxygenation (PADECMO)

Recruiting now · Not applicable

Conditions studied: Pharmacokinetics, Amoxicillin-clavulanate, Piperacillin-tazobactam, Meropenem, Cefazolin, Teicoplanin, Vancomycin, Ciprofloxacin, Amikacin

In brief

Pharmacokinetics of antibiotics in critically ill neonates, infants and children on extracorporeal membrane oxygenation (ECMO).

Key facts

Study ID

NCT06426836

Run by

University Hospital, Ghent

People needed

300

Starts

2016-08-19

Expected to finish

2026-07-01

Last updated by the study team

2026-01-16

Who can join

Age: any, up to 15. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• patients admitted to the pediatric intensive care unit or cardiac intensive care unit
• patient age : 1,8 kg-15 years
• patient receiving antibiotic treatment (piperacillin-tazobactam, meropenem, amoxicillin-clavulanate, cephazolin, vancomycin, teicoplanin, ciprofloxacin, amikacin)
• intra-arterial or intravenous access other than the drug infusion line available for blood sampling (arterial line is preferred)
• extracorporeal membrane oxygenation circuit

You may not qualify if…

• no catheter in place for blood sampling
• absence of parental/patient consent
• known hypersensitivity to beta-lactam antibiotics and ciprofloxacin

Where it is running

• Queen Fabiola Children's University Hospital — Brussels, Brussels Capital, Belgium (enrolling)
• University Hospital — Ghent, Belgium (enrolling)
• Universitair hospital — Leuven, Belgium (enrolling)

Full record on ClinicalTrials.gov

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