Insulin and Insulin Pulses During Fasting

Recruiting now · Not applicable

Conditions studied: PreDiabetes

In brief

Fasting hyperglycemia contributes disproportionately to nonenzymatic glycosylation and the microvascular complications of type 2 diabetes. However, little is known about the regulation of glucose concentrations in the fasting state relative to what is known about the postprandial state. The proposed experiment is part of a series of experiments designed to establish how glucagon and insulin interact with their receptors to control fasting glucose in health and in prediabetes.

Key facts

Study ID

NCT06424015

Run by

Mayo Clinic

People needed

60

Starts

2024-09-15

Expected to finish

2027-09-01

Last updated by the study team

2025-10-01

Who can join

Age: 25 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• people with normal or impaired fasting glucose and normal or impaired glucose tolerance

You may not qualify if…

• HbA1c > 6.5%
• BMI ≥ 35 Kg/M2
• Use of any glucose-lowering agents including metformin or sulfonylureas.
• For female subjects: positive pregnancy test at the time of enrollment or study
• History of prior upper abdominal surgery such as adjustable gastric banding, pyloroplasty and vagotomy.
• Active systemic illness or malignancy.
• Symptomatic macrovascular or microvascular disease.
• Hematocrit < 35%

Where it is running

• Mayo Clinic in Rochester — Rochester, Minnesota, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.