A Rapid Triage Test to Improve Risk-stratification of Febrile Children (EChiLiBRiST, Clinical Trial 1, Outpatients)
Recruiting now · Not applicable
Conditions studied: Infectious Disease, Febrile Illness, Child, Only
In brief
The overall aim of the study is to provide evidence that introducing novel biomarkers evaluation at triaging (first clinical assessment), in combination with IMCI-based guidelines (SoC), is a viable strategy to enhance rapid and accurate identification of febrile children at increased risk of life-threatening infections compared to IMCI-based strategies alone (SoC), and to demonstrate whether this results in enhanced decisions of admission/referral vs discharge, and enhanced overall health outcome of children with acute fever in sub-Saharan Africa.
Key facts
- Study ID
- NCT06422338
- Run by
- Barcelona Institute for Global Health
- People needed
- 5212
- Starts
- 2025-07-02
- Expected to finish
- 2027-08-31
- Last updated by the study team
- 2026-07-28
Who can join
Age: 0 and older, up to 5. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥2 months and <60 months
- Written informed consent from the child's parent or caregiver
- History of fever for ≤7 days OR hypothermia (i.e., axillary temperature <35.5ºC) OR suspected severe infection (e.g., in children with moderate or severe acute malnutrition).
- Lives within the catchment area of the study facility and must intend to continue to reside there for the duration of the study
- For the RTI sub-study only: presence of respiratory symptoms compatible with RTI.
You may not qualify if…
- Weight less than 2.5kg
- Main reason for consultation is an injury, trauma or acute poisoning
- Enrolled in another clinical trial testing a new drug
- Enrolled in a vaccine trial in the last 3 months.
- Any other condition determined by the investigators that makes it unlikely that the participant would complete the study
Where it is running
- CERMEL Centre de Recherches Médicales de Lambaréné — Lambaréné, Moyen-Ogooué Province, Gabon (enrolling)
- Mopeia Sede Health Centre — Mopeia, Mozambique (enrolling)
Full record on ClinicalTrials.gov
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