Incidence and Impact of ICU-acquired Diaphragm Weakness
Recruiting now
Conditions studied: Diaphragm Dysfunction
In brief
ICU survivors are at an increased risk of hospital and ICU readmission. Among the complications of ICU stay, diaphragmatic dysfunction is common, with a prevalence of 60 to 80%, and is associated with increased mortality and prolonged hospital stays. Furthermore, several studies have reported that the observation of impaired respiratory muscle function upon ICU discharge is associated with a poor long-term prognosis. However, the incidence and prognostic impact of persistent diaphragmatic dysfunction at ICU discharge have never been evaluated. The measurement of dyspnea, a composite evaluation of respiratory muscle function, has not been assessed for predicting prognosis upon ICU discharge. The hypothesis of the project is that the presence of ICU-acquired diaphragmatic dysfunction at ICU discharge is associated with a poorer prognosis within 90 days.
Key facts
- Study ID
- NCT06420999
- Run by
- Assistance Publique - Hôpitaux de Paris
- People needed
- 194
- Starts
- 2024-07-29
- Expected to finish
- 2028-01-29
- Last updated by the study team
- 2025-05-28
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥ 18 years
- Invasive or non-invasive respiratory support (ventilation, high-flow oxygen therapy, whatever the reason) for at least 48 hours.
- Weaning from respiratory support (invasive or not) within the last 24 hours.
- Patient (or trusted person/relative) informed and not opposed to the study.
You may not qualify if…
- Known pre-existing diaphragmatic dysfunction (phrenic lesion, neuromuscular disease, etc.)
- Patients with tracheostomy
- Non-communicating patients
- Patients deprived of liberty by court or administrative order, or under legal protection (guardianship, curators).
Where it is running
- Médecine intensive Réanimation — Paris, France (enrolling)
Full record on ClinicalTrials.gov
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