Resistance Exercise and Creatine in Colorectal Cancer

Completed · Not applicable · Has a placebo group

Conditions studied: Colorectal Cancer

In brief

Low skeletal muscle mass and function, is prevalent in up to 60% of colorectal cancer patients. This condition arises from a combination of factors such as aging, inactivity, treatment side effects, malnutrition, tumor burden, and inflammation. Given this complexity, singular interventions may not be sufficient to address low muscle mass in this group. Creatine monohydrate, a compound vital for energy during exercise, has been extensively researched and proven safe and effective across various demographics, including older adults and clinical populations. Studies show that creatine enhances benefits from resistance training, indicating potential to counter muscle mass and function decline post-cancer treatment. This study aims to assess the feasibilty of combining creatine supplementation with resistance training versus resistance training alone in colorectal cancer survivors treated with chemotherapy. A randomized controlled pilot trial will compare a 10-week program of resistance exercise plus creatine (EXSUPP) with resistance exercise alone (EXPLA), each with 20 participants.

Key facts

Study ID

NCT06420726

Run by

University of South Carolina

People needed

27

Starts

2023-09-01

Expected to finish

2025-09-15

Last updated by the study team

2026-06-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Individuals ≥12 months post treatment with chemotherapy for colorectal cancer
• >18 years

You may not qualify if…

• are receiving active treatment for their cancer;
• had a musculoskeletal, cardiovascular, neurological, or psychological condition that precluded participation in RET;
• had been participating in structured RET two or more times per week for the past 6 months
• are currently taking supplements containing creatine for 4 weeks prior to the start of the RCT, or
• are receiving medications that might alter body composition (metformin, corticosteroids etc.).

Where it is running

• University of South Carolina — Columbia, South Carolina, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.