The Causal Effect of Bariatric Surgery on Cardiovascular Disease and Mortality
Recruiting now
Conditions studied: Bariatric Surgery Candidate, Cardiovascular Diseases, Morality
In brief
The association between weight, and cardiovascular disease and mortality is well established, however, the causal effect of weight-loss in midlife on these outcomes is less clear. Bariatric surgery results in substantial weight-loss and is an ideal candidate to study the causal effects of weight-loss. The investigators propose a project that will use causal inference and machine learning methods to answer two important questions: 1. Is bariatric surgery effective for reducing cardiovascular disease and mortality, and if so, for who? 2. Which type of bariatric surgery (gastric bypass or sleeve gastrectomy) is most effective, and for who? The investigators will use data from various Swedish registers to identify individuals with obesity who are eligible for bariatric surgery. We will then compare cardiovascular and mortality outcomes among those undergoing different types of bariatric surgery with those receiving non-surgical obesity management using causal inference methods. The investigators will use causal forests and expert knowledge to estimate indiviual treatment effects, and identify the groups of patients who benefit the most from these surgeries.
Key facts
- Study ID
- NCT06420479
- Run by
- Karolinska Institutet
- People needed
- 100000
- Starts
- 2024-01-01
- Expected to finish
- 2027-12-31
- Last updated by the study team
- 2024-06-17
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Men and women of reproductive age with a diagnosis of obesity, no prior history of cardiovascular disease or cancer, and no contraindications for surgery after 1982
You may not qualify if…
- Contraindications to bariatric surgery
Where it is running
- Karolinska Institutet — Stockholm, Sweden (enrolling)
Full record on ClinicalTrials.gov
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