The Correlation of Intracranial Artery Calcification and Outcomes of Mechanical Thrombectomy

Recruiting now

Conditions studied: Stroke, Acute, Ischemic Stroke, Vascular Diseases, Central Nervous System Diseases, Nervous System Diseases, Stroke, Brain Diseases, Cerebrovascular Disorders, Intracranial Arterial Calcification

In brief

CAIS-MT is a single-center, prospective cohort study, to evaluate the correlation between outcomes of endovascular treatment(EVT) and intracranial artery calcification(IAC) in patients with acute ischemic stroke due to large or medium vessel occlusion.

Key facts

Study ID

NCT06418698

Run by

Zhujiang Hospital

People needed

434

Starts

2024-03-28

Expected to finish

2029-06-01

Last updated by the study team

2025-07-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or non-pregnant women with acute stroke symptoms aged over 18 years.
• Occlusion of the intracranial internal carotid artery, the middle cerebral artery, the anterior cerebral artery, the posterior cerebral artery, basilar artery and intracranial vertebral artery confirmed by CT, MR angiography, or digital subtraction angiography.
• No absolute contraindication to iodinated contrast media.
• Planned treatment with EVT by clinical care team.
• Informed consent obtained from patients or their legal representatives.
• Willing to be followed up as required by the clinical study protocol.

You may not qualify if…

• Acute ischemic stroke occurs over 24 hours of time last known well.
• Neurologic deficits caused by diagnoses other than ischemic stroke, such as intracerebral hemorrhage, subarachnoid hemorrhage, or intracranial tumors.
• With other underlying factors leading to IAC, such as hyperthyroidism, end-stage renal disease, long-term oral intake of vitamin K antagonist(Warfarin), chronic vitamin D deficiency or overdose, persistent hypomagnesemia, persistent hypercalcemia, persistent hyperphosphatemia and high oral calcium intake.
• Lack of non-contract CT images on admission and significant artifacts in CT images preventing IAC measurement.
• Severe renal insufficiency (estimated glomerular filtration rate < 30ml/min or serum creatinine > 220μmol/L (2.5mg/dl)).
• Previous cerebrovascular intervention treatment or craniotomy.

Where it is running

• Zhujiang Hospital, Southern Medical University — Guangzhou, Guangdong, China (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.