Intrathecal Dexmedetomidine vs Epinephrine
Completed · Phase 4
Conditions studied: Cesarean Section, Anesthesia, Spinal
In brief
Several studies have shown that adding dexmedetomidine or epinephrine to single-dose spinal analgesia preparations improves the length and/or speed of onset of the sensory block and post-operative pain management without increased negative side effects. To date, however, no study has compared adjunctive intrathecal dexmedetomidine to adjunctive intrathecal epinephrine in single-dose spinal analgesia. The purpose of this study is to determine if adjunctive intrathecal dexmedetomidine is non-inferior to adjunctive intrathecal epinephrine in providing better single-dose spinal analgesia during cesarean section.
Key facts
- Study ID
- NCT06418308
- Run by
- Icahn School of Medicine at Mount Sinai
- People needed
- 90
- Starts
- 2024-09-17
- Expected to finish
- 2026-05-21
- Last updated by the study team
- 2026-06-17
Who can join
Age: 18 and older, up to 55. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Pregnant patients
- aged 18-55 years
- presenting for scheduled primary or secondary cesarean section
- candidates for single shot spinal anesthesia singleton pregnancy
You may not qualify if…
- patient refusal of spinal anesthetic
- if patient is not a candidate for spinal anesthesia due to history of coagulopathy, elevated intracranial pressure, infection at site of injection, etc.
- emergency cesarean section
- preexisting motor or sensory deficit
- suspected pre-eclampsia
- patient receiving combined spinal-epidural as anesthetic technique
- BMI > 40
Where it is running
- Mount Sinai Hospital — New York, New York, United States
Full record on ClinicalTrials.gov
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