Retinal Vessel Leakage in Cerebral Small Vessel Disease
Recruiting now
Conditions studied: Cerebral Small Vessel Diseases, Lacunar Stroke, Vascular Dementia
In brief
The goal of this observational study is to learn about leakage from retinal vessels in cerebral small vessel disease. The main questions it aims to answer are: * Does retinal vessel leakage occur in cerebral small vessel disease? * If it does, is the severity of retinal vessel leakage similar to the severity of cerebral small vessel disease generally? Participants will be tested using fluorescein angiography. This involves an intravenous injection of fluorescent dye, and is a very sensitive way to find leakage from retinal blood vessels. Participants will have already had brain scans and other examinations and tests to measure the severity of their cerebral small vessel disease. Our new retinal images will complement the information from these previous tests.
Key facts
- Study ID
- NCT06416371
- Run by
- University of Edinburgh
- People needed
- 40
- Starts
- 2025-01-13
- Expected to finish
- 2029-02-15
- Last updated by the study team
- 2026-03-04
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Membership in the Mild Stroke Study 3 cohort
- Contrast enhanced MRI within 12 months
- Clear optical media in both eyes, as assessed by study investigator
- Best corrected visual acuity (near vision) ≥N36
You may not qualify if…
- Any condition known to cause retinal leakage (i.e., worse than background diabetic retinopathy, retinal vein occlusion, active uveitis, wet age-related macular degeneration, malignant hypertension)
- Previous treatment for retinal leakage (retinal laser, intravitreal anti-VEGF)
- Recent eye surgery
- Shallow anterior chambers as assessed by torch test
- Pregnancy, renal failure
- Severe dementia
- Known allergy to fluorescein
- History of allergy such as food or drug induced urticaria or history of bronchial asthma
- Any other severe or acute medical or psychiatric conditions
- Inability to give informed consent
Where it is running
- NHS Lothian — Edinburgh, United Kingdom (enrolling)
Full record on ClinicalTrials.gov
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