Lattice Radiotherapy for Dose-Escalated Palliation of Bulky Tumors
Recruiting now · Phase 2
Conditions studied: Cancer, Metastatic Cancer, Locally Advanced, Locally Advanced Solid Tumor, Locally Advanced Carcinoma
In brief
The purpose of this research study is to determine if lattice radiation therapy (LRT) will provide better treatment for bulky (large) tumors than current standard of care radiotherapy.
Key facts
- Study ID
- NCT06416007
- Run by
- University of Cincinnati
- People needed
- 37
- Starts
- 2024-08-02
- Expected to finish
- 2027-06-01
- Last updated by the study team
- 2026-05-04
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Solid tumor malignancy with a clinical indication for radiation
- Patients must have measurable disease
- Target lesion(s) which are amenable to lattice therapy plan
- When applicable, target lesion for radiation amenable to immobilization during delivery of radiotherapy
- Age ≥18 years.
- ECOG Performance status ≤2
- Life expectancy greater than 3 months
- Women of child-bearing potential and men must agree to avoid conception via abstinence (ideal) or a method of birth control (e.g., hormonal or barrier method of birth control) prior to study entry and for at least 30 days after completion of lattice therapy administration.
- Ability to understand and the willingness to sign a written informed consent document
You may not qualify if…
- Patients receiving cytotoxic chemotherapy or known radiosensitizing agents within 5 days before or after lattice therapy.
- Patients with hematologic malignancies including lymphoma and leukemia as well as primary or metastatic central nervous system (CNS) malignancies.
- Patients with a history of conditions which predispose them to increased radiation toxicity
- Patients with known contraindications to radiation therapy
- Patients with uncontrolled intercurrent illness
- Pregnant women
Where it is running
- University of Cincinnati Medical Center — Cincinnati, Ohio, United States (enrolling)
Full record on ClinicalTrials.gov
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