A First-In Human (FIH) Study to Find Out How Well REGN10597 Medicine Given Alone or in Combination With Cemiplimab Works in Adult Participants Who Have Cancer With Tumors That Have Spread in Their Body
Recruiting now · Phase 1/Phase 2
Conditions studied: Melanoma, Clear-Cell Renal-Cell Carcinoma (ccRCC), Advanced Solid Tumors
In brief
This study is researching an experimental drug called REGN10597 alone or in combination with another drug called cemiplimab (called "study drug(s)"). The study is focused on patients with certain solid tumors that are in an advanced stage. The aim of the study is to see how safe, tolerable, and effective the study drug(s) are. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug(s) * How much study drug(s) is in the blood at different times * Whether the body makes antibodies against the study drug(s) (which could make the study drug(s) less effective or could lead to side effects)
Key facts
- Study ID
- NCT06413680
- Run by
- Regeneron Pharmaceuticals
- People needed
- 240
- Starts
- 2024-09-23
- Expected to finish
- 2030-02-03
- Last updated by the study team
- 2026-04-28
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- USC Norris Comprehensive Cancer Center — Los Angeles, California, United States (enrolling)
- University of California San Francisco (UCSF) — San Francisco, California, United States (enrolling)
- Yale School of Medicine — North Haven, Connecticut, United States (enrolling)
- University of Chicago — Chicago, Illinois, United States (enrolling)
- Start Midwest Cancer Research — Grand Rapids, Michigan, United States (enrolling)
- Northwell Health — Lake Success, New York, United States (enrolling)
- University of North Carolina at Chapel Hill — Chapel Hill, North Carolina, United States (enrolling)
- University of Pittsburgh Medical Center - Hillman Cancer Center — Pittsburgh, Pennsylvania, United States (enrolling)
- MD Anderson Cancer Center — Houston, Texas, United States (enrolling)
- Next Oncology — San Antonio, Texas, United States (enrolling)
- The Start Center for Cancer Care — San Antonio, Texas, United States (enrolling)
Full record on ClinicalTrials.gov
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