Risk Factors for Non-response to Hormonal Medical Therapy in Patients With Endometriosis

Recruiting now

Conditions studied: Endometriosis

In brief

Determine the proportion of patients with endometriosis unresponsive to medical therapy and to compare the clinical and ultrasonographic characteristics of this group of patients (study group) with the clinical and ultrasonographic characteristics of patients responsive to medical therapy (control group).

Key facts

Study ID

NCT06413381

Run by

IRCCS Azienda Ospedaliero-Universitaria di Bologna

People needed

250

Starts

2024-04-19

Expected to finish

2029-11-28

Last updated by the study team

2024-08-01

Who can join

Age: 18 and older, up to 50. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• age between 18 and 50 years;
• patients with endometriosis-related pain symptoms (dyspareunia, dyschezia, dysmenorrhea, chronic pelvic pain, dysuria, periovulatory pain, with at least one of these symptoms presenting Numerical Pain Rating Scale intensity > 5);
• indication for administration of oral hormonal medical treatment for endometriosis;
• acquisition of informed consent.

You may not qualify if…

• patients with contraindications to oral hormone treatment
• current or previous pelvic infections
• history of malignancy or current suspicion of gynecologic malignant lesions
• previous pelvic surgery (hysterectomy, salpingectomy, ovarian cyst removal, myomectomy, surgery for endometriosis, bowel resections)
• positive history of other causes of chronic pelvic pain
• post-menopausal status

Where it is running

• IRCCS Azienda Ospedaliero-Universitaria, Policlinico Sant'Orsola — Bologna, BO, Italy (enrolling)

Full record on ClinicalTrials.gov

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