The Natural History and Biological Study of Pulmonary Recurrent Respiratory Papillomatosis (pRRP)

Recruiting now

Conditions studied: Recurrent Respiratory Papillomatosis, Pulmonary Neoplasm

In brief

Recurrent respiratory papillomatosis (RRP) is an orphan disease that affects approximately 20,000 people in the United States and is caused by infection with human papillomavirus (HPV) types 6 and 11. Since RRP is an orphan disease, it is an understudied disease entity with correspondingly few treatment options. The investigators hypothesize that by understanding the biology of RRP and the failed host immune responses against HPV, novel and rational therapies can be developed. This study will examine the genetic and immunologic alterations found in these rare tumors and distant metastatic involved sites (such as the lung) in patients diagnosed with RRP.

Key facts

Study ID

NCT06412172

Run by

Massachusetts General Hospital

People needed

100

Starts

2024-04-15

Expected to finish

2030-04-15

Last updated by the study team

2025-08-12

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• History of HPV-associated Recurrent Respiratory Papillomatosis
• Has pulmonary lesions

You may not qualify if…

• None

Where it is running

• Yale School of Medicine — New Haven, Connecticut, United States (enrolling)

Full record on ClinicalTrials.gov

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