Blood Flow Conditions and Sounds in AVFs

Recruiting now · Not applicable

Conditions studied: End Stage Renal Disease

In brief

This is a prospective non-pharmacological interventional study aimed at investigating the relationship between the blood flow condition and the arteriovenous fistula (AVF) sound, with the ultimate aim of predicting the AVF clinical, in patients with end-stage renal disease (ESRD) who require the creation of a vascular access for extracorporeal circulation.

Key facts

Study ID

NCT06411353

Run by

Mario Negri Institute for Pharmacological Research

People needed

15

Starts

2025-03-01

Expected to finish

2028-02-01

Last updated by the study team

2025-09-04

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Provision of informed consent prior to any study specific procedures.
• Female and/or male aged between 18 and 90 years.
• Patients in HD treatment who need a new VA or patients who entered the pre-dialysis program because of ESRD. In all cases, the first-choice treatment is the surgical creation of an autogenous AVF in patient's forearm.

You may not qualify if…

• Contraindications for the creation of an autogenous AVF.
• Presence of a previously failed AVF in the same arm selected for surgery.
• Patients with contraindications to MRI including: pregnancy, claustrophobia, cardiac pacemakers or other MRI-incompatible prostheses.
• Patients already on HD treatment through a catheter or a graft.
• Patients undergoing peritoneal dialysis.
• Patients with a life expectancy of less than 2 years.

Where it is running

• A.O. Papa Giovanni XXIII - U.O. Nefrologia e Dialisi — Bergamo, Bergamo, Italy (enrolling)

Full record on ClinicalTrials.gov

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