Efficacy and Safety of Local Glucocorticoids for the Treatment of Acute Radiation-Induced Intestinal Injury

Recruiting now · Not applicable

Conditions studied: Radiation-Induced Intestinal Injury

In brief

Due to the increasing number and prolonged survival of malignant tumor patients treated with radiotherapy, the complication, such as acute radiation-induced intestinal injury, has become increasingly significant. Glucocorticoids may play a therapeutic role by regulating the inflammatory response in patients with acute radiation-induced intestinal injury. However, the conclusions of related studies were controversial.

Key facts

Study ID

NCT06410443

Run by

General Hospital of Shenyang Military Region

People needed

60

Starts

2024-08-01

Expected to finish

2026-12-31

Last updated by the study team

2025-12-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Grade II-III acute radiation-induced rectosigmoid injury
• Signed informed consents
• Age ≥18 years
• Rstimated survival time >1 year

You may not qualify if…

• Absolute contraindications to glucocorticoids
• A history of glucocorticoids treatment within 3 months
• Inflammatory bowel disease or infectious intestinal disease
• Recurrence of malignant tumor
• Colorectal cancer or metastasis
• Severe heart or lung diseases
• Recent history of surgery or trauma
• Poorly controlled hyperglycemia and hypertension
• Active tuberculosis
• Ssevere gastrointestinal ulcers
• Glaucoma
• Sychiatric diseases
• Pregnant or lactating

Where it is running

• Department of Gastroenterology, General Hospital of Northern Theater Command (formerly called General Hospital of Shenyang Military Area) — Shenyang, Liaoning, China (enrolling)

Full record on ClinicalTrials.gov

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