Mood and Decision-making in Methamphetamine Use Disorder
Completed · Not applicable
Conditions studied: Methamphetamine Abuse
In brief
In this project, the investigators examine behavior and associated brain activity during explore-exploit decision-making tasks performed pre- and post-modulation of affective state using autobiographical memory recall. The investigators hypothesize that a positive memory recall will reduce negative affective state, reduce explore-exploit biases and normalize the associated brain activity. The investigators propose a randomized double-blind, sham-controlled trial of positive autobiographical memory recall with 80 adults (n=40 per arm) with methamphetamine use disorder (MUD) currently involved in abstinence only treatment centers.
Key facts
- Study ID
- NCT06410196
- Run by
- Laureate Institute for Brain Research, Inc.
- People needed
- 80
- Starts
- 2024-07-26
- Expected to finish
- 2026-03-23
- Last updated by the study team
- 2026-06-16
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adults 18-65 years old
- English proficiency as evaluated by language ability during screening
- Past-year diagnosis of DSM-5 methamphetamine use disorder (MUD) confirmed by the MINI
- Actively enrolled in treatment for substance use disorder.
You may not qualify if…
- Severe traumatic brain injury (as indicated by a score ≥3 on the Tulsa Head Injury Screen
- Any medical condition interfering with the participation in the study as determined by medical screening
- DSM-5 diagnosis of psychotic disorders, bipolar I disorder, or major depressive disorder with psychosis
- fMRI contraindications as listed on the MR environment screening form
- Positive breathalyzer for alcohol
- Positive urine drug screening, except for cannabis or prescribed benzodiazepines, as indicated in the medical screening
- Evidence of inability to comply with study procedures based on judgement of the experimenter.
Where it is running
- Laureate Institute for Brain Research — Tulsa, Oklahoma, United States
Full record on ClinicalTrials.gov
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