Comparing Moderately Ultra Hypofractionated Radiation Treatments for Prostate Cancer

Recruiting now · Phase 2

Conditions studied: Post-Operative Prostate Cancer

In brief

This is a multi-institution, randomized, non-inferiority Phase II trial comparing external beam radiotherapy delivered as 54 Gy in 20 fractions to prostate bed +/- 44 Gy in 20 fractions to pelvic lymph nodes delivered daily with external beam radiotherapy delivered as 30 Gy in 5 fractions to prostate bed +/- 25 Gy in 5 fractions to pelvic lymph nodes delivered on alternate days.

Key facts

Study ID

NCT06409910

Run by

University Health Network, Toronto

People needed

204

Starts

2024-11-26

Expected to finish

2030-11-01

Last updated by the study team

2026-03-23

Who can join

Age: 18 and older. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Age >/= 18 years
• Able to provide informed consent
• Histologic diagnosis of prostate adenocarcinoma
• ECOG performance status 0-1
• Previous radical prostatectomy > 6 months prior to radiotherapy start date
• Planned to receive post-operative radiation

You may not qualify if…

• Prior pelvic radiotherapy
• Contraindications to radiotherapy
• Confirmed metastases (if scan has been done for clinical care)
• Participants with visible disease in the prostate bed or pelvic lymph nodes on imaging are not eligible for treatment on study.

Where it is running

• London Health Sciences Centre — London, Ontario, Canada (enrolling)
• University Health Network - Princess Margaret Cancer Centre — Toronto, Ontario, Canada (enrolling)

Full record on ClinicalTrials.gov

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