Impact of Environmental Exposures on Tumor Risk in SDHx-mutation Carriers

Recruiting now

Conditions studied: SDH-Related Familial Paraganglioma, SDHx-Related Syndromes, SDH Gene Mutation, Environmental Exposure

In brief

The primary objective of the PGL.EXPO-2 study is to test the hypothesis that exposure (occupational, environmental and/or domestic) to succinate dehydrogenase inhibitors (SDHi) could contribute to tumor emergence in subjects carrying a germline mutation in one of the SDHx genes.The primary endpoint will be the proportion of subjects (cases or controls) exposed to SDHi and the association with paraganglioma risk. In addition, a blood sample (10 ml on EDTA) will be proposed to the participants to the study

Key facts

Study ID

NCT06408402

Run by

Assistance Publique - Hôpitaux de Paris

People needed

1300

Starts

2024-05-22

Expected to finish

2028-05-22

Last updated by the study team

2026-07-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Cases: SDHx mutation carriers diagnosed for a SDHx-related tumor
• Controls: SDHx mutation carriers with no SDHx-related tumor

You may not qualify if…

• Incapacity to exercise free and informed consent for the study
• Patient under tutorship or guardianship or legal safeguard

Where it is running

• Hôpital européen Georges Pompidou - APHP — Paris, France (enrolling)
• CHU Jean Minjoz Besançon — Besançon, France
• Hôpital Louis Pradel — Bron, France
• CHU de Caen — Caen, France
• Hôpital Michalon - CHU Grenoble — Grenoble, France
• CHU de Lille - Hôpital HURIEZ — Lille, France
• Hopital de la Conception - Marseille — Marseille, France
• CHU de Montpellier - Hôpital Lapeyronie — Montpellier, France
• CHU de Nantes — Nantes, France
• CHU de Nice -Hôpital Archet 2 — Nice, France
• Hôpital Pitié-Salpêtrière - APHP — Paris, France
• Hôpital Cochin - APHP — Paris, France
• Hôpital européen Georges Pompidou - APHP — Paris, France
• CHU de Poitiers — Poitiers, France
• CHU de Rennes - Hôpital Sud — Rennes, France
• Hôpitaux universitaire de Strasbourg - Hôpital de Hautepierre — Strasbourg, France
• CHU de Toulouse - Hôpita Larrey — Toulouse, France
• CHU Bretonneau — Tours, France
• CHU d'Angers — Angers, France
• Institut Gustave Roussy — Villejuif, France

Full record on ClinicalTrials.gov

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