Perioperative Multimodal Analgesia Protocol for Supratentorial Craniotomy

Starting soon · Not applicable · Has a placebo group

Conditions studied: Postoperative Pain, Analgesia, Supratentorial Brain Tumor

In brief

Supratentorial craniotomy is one of the most common neurosurgical procedures, with severe perioperative pain. Inadequate perioperative pain relief has been associated with increased blood pressure and intracranial pressure, favoring bleeding and cerebral cerebral hypoperfusion. The ideal analgesia for neurosurgery requires complete pain relief, eliminates the side effects of opioid drugs and no influence for neurological function. Previous studies have proposed a multimodal analgesic strategy, combining analgesics and local anaesthesia, it is expected to achieve the above benefits.

Key facts

Study ID

NCT06406829

Run by

Beijing Tiantan Hospital

People needed

2000

Starts

2026-02-09

Expected to finish

2027-12-31

Last updated by the study team

2026-02-11

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Aged from 18 to 65 years
• American Society of Anesthesiologists physical status I to III
• Scheduled to undergo elective supratentorial tumor resection

You may not qualify if…

• Incision-area skin infection
• A history of previous craniotomy
• Allergy to study medications
• A history of preoperative change in consciousness or cognitive function
• Severe hepatic or renal dysfunction
• Severe bradycardia (heart rate<40 beats/min)
• Sick sinus syndrome or second- to-third degree atrioventricular block

Full record on ClinicalTrials.gov

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