Chronic Lung Allograft Dysfunction MRI Study

Recruiting now · Phase 1/Phase 2

Conditions studied: Chronic Lung Allograft Dysfunction Lung MRI (CLAD)

In brief

This studies purpose is to confirm the efficacy and efficiency of using OE-MRI and MRI with hyperpolarized gas techniques and Iodinated contrast CT scan, this will enhance understanding of CLAD pathophysiology. Moreover, this project is foundational to performing additional studies to establish if novel MRI imaging can serve as an objective confirmatory diagnostic tool for CLAD in post-transplant patients.

Key facts

Study ID

NCT06406777

Run by

Sean Fain

People needed

100

Starts

2025-03-20

Expected to finish

2028-09-01

Last updated by the study team

2026-08-06

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may not qualify if…

• SAO2 drops below 90% (in absence of mechanical failure) during normal tidal breathing
• Unilateral diaphragm paralysis
• Evidence of acute illness on day of study
• Evidence of restrictive lung disease
• Dependence on supplemental oxygen
• History of cardiac disease
• Pregnancy (self-declared)
• Lactating women
• Participants with metal objects in their body
• Known contraindication to MRI examination
• Systolic blood pressure reading of < 100 mmHg or > 200 mmHg
• Diastolic blood pressure reading of <60 mmHg or > 100 mmHg

Where it is running

• University of Iowa — Iowa City, Iowa, United States (enrolling)

Full record on ClinicalTrials.gov

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