Detection of Vocal Fold Motion Impairment on Noninvasive Positive Pressure

Recruiting now

Conditions studied: Vocal Cord Dysfunction, Vocal Cord Paralysis, Vocal Cord Paresis, Recurrent Laryngeal Nerve Palsy, Recurrent Laryngeal Nerve Injuries

In brief

The goal of this prospective, observational study is to evaluate for the presence of vocal fold motion impairment (VFMI) in the children admitted to the pediatric intensive care unit on noninvasive positive pressure ventilation (NIV PPV). Participants will have two ultrasounds of their vocal folds performed, once while on NIV PPV and once after weaned off of the NIV PPV. This results of these scans will be reviewed against one another and against the gold standard, fiberoptic nasolaryngoscopy (FNL). The main question this study aims to answer is: Can POCUS be used to reliably detect VFMI while pediatric patients on supported with NIV PPV?

Key facts

Study ID

NCT06406725

Run by

Nemours Children's Clinic

People needed

50

Starts

2024-03-30

Expected to finish

2028-05-30

Last updated by the study team

2026-05-06

Who can join

Age: 0 and older, up to 18. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 0 to 18 years
• Scheduled to receive a fiberoptic nasolaryngoscopy with the otolaryngology team to assess for vocal fold motion impairment
• Status post great vessel, esophageal, or tracheal surgery that could disrupt the recurrent laryngeal nerve

You may not qualify if…

• Tracheostomy in place
• Age >18 years
• History of vocal cord paralysis/paresis
• Patients who cannot have their neck placed in a neutral or slightly extended position due to injury or ligament laxity

Where it is running

• Cohen Children's Medical Center — Queens, New York, United States (enrolling)

Full record on ClinicalTrials.gov

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