Micro-movements in Patients With Prolonged Disorders of Consciousness
Recruiting now
Conditions studied: Consciousness Disorders
In brief
The goal of this observational study is to learn about the micro-movements in patients with prolonged disorders of consciousness. The main questions it aims to answer are: Use the neuropsychological paradigm model to monitor micro-movements, assess the patient's remaining level of consciousness and accurately classify it; screen out patients with cognitive-motor dissociation to improve the prognosis of cognitive function; explore the remaining brain function of patients with chronic disorders of consciousness and promote relevant study of neural mechanisms. Participants will be subjected to consciousness assessment by CRS-r scale, and their micro-movement changes in response to various emotional stimuli will be captured, along with the collection of EEG and MRI data. Follow-up evaluations will be conducted using the CRS-R scale and GOS scale, with a follow-up period of 6 months.
Key facts
- Study ID
- NCT06406413
- Run by
- First Affiliated Hospital of Zhejiang University
- People needed
- 179
- Starts
- 2024-05-01
- Expected to finish
- 2026-12-01
- Last updated by the study team
- 2026-01-14
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Patients with consciousness disorders for more than 28 days following severe brain injury, assessed by the CRS-R scale to meet the criteria for VS or MCS;
- Aged between 18 and 80 years;
- Stable vital signs;
- Voluntary participation of family members with signed informed consent;
- Good cooperation, minimal facial and spontaneous activities, no use of antiepileptic or sedative drugs.
You may not qualify if…
- Locked-in syndrome;
- Contraindications for EEG examination;
- Contraindications for MRI scanning, such as the presence of internal metallic implants;
- Diseases and factors that may affect brain function assessment, such as metabolic disorders, poisoning, shock, etc.
Where it is running
- First Affiliated Hospital,Zhejiang University — Hanzhou, Zhejiang, China (enrolling)
Full record on ClinicalTrials.gov
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