Left Atrial Appendage Arrhythmogenic and Thrombogenic Substrate

Recruiting now · Not applicable

Conditions studied: Atrial Fibrillation, Stroke

In brief

The purpose of the project is to elucidate whether it is possible to identify which patients are at risk of forming blood clots that can cause stroke based on analysis of the electrocardiogram. In connection with the operation, the small pouch known as the auricle of the heart is closed, which can be completely removed after closing. This procedure is common in patients with atrial fibrillation to protect the brain from stroke. In the project, all patients will have this auricle closed if they agree to participate in the project. After closure, the auricle is usually discarded. We will analyze the blood and the auricle tissue taken (if available) in connection with the operation itself, together with the analysis of the electrocardiogram recorded before the planned heart operation.

Key facts

Study ID

NCT06405750

Run by

University Hospital Bispebjerg and Frederiksberg

People needed

1000

Starts

2024-08-01

Expected to finish

2035-12-31

Last updated by the study team

2026-01-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• signed informed consent AND
• planned any open-heart surgery:
• CABG
• valve repair or replacement
• aorta surgery
• any combination of the above

You may not qualify if…

• current endocarditis
• follow-up not possible

Where it is running

• Rigshospitalet — Copenhagen, Denmark (enrolling)

Full record on ClinicalTrials.gov

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